Berberine and metformin are each separately recommended for managing type 2 diabetes. However, it is generally acceptable to take Berberine together with Metformin. And in fact, the two may actually complement one another in supporting healthy body function in the near term. In studies, Berberine is effective in lowering blood sugar and helping to manage this condition. Berberine has fewer side effects and a greater potential for reducing dangerous cardiovascular risk factors over Metformin. It is certainly worth considering a trial of Berberine.